Members of other genera, Norovirus and Sapovirus, cause gastrointestinal disease in humans. Viral replication is cytoplasmic. Cats can easily transmit URIs, like calicivirus. For diagnosis, pay attention to symptoms in your cat, and if you suspect that your cat has been affected, take it to … Establishing stable plaque variants serial plaque purification (FCV passaged in Crandell-Rees Feline Kidney cells - CRFK cells) has proven challenging as reducing the variation in plaque size requires at least 15 serial purification steps. The vesiviruses include feline calicivirus … ImpactsWhat was accomplished under these goals? The virus is present in saliva, tears and nasal secretions and spread through contact between cats. What opportunities for training and professional development has the project provided? Several mutants have been selected and analysis on their biology has been initiated. Changes/Problems: Calicivirus and other feline URIs are highly contagious infections that can result in mild to severe clinical signs (especially in immunosuppressed or very young kittens). In humans, caliciviruses are a major cause of acute gastroenteritis, while in animals respiratory illness, conjunctivitis, stomatitis, and hemorrhagic disease are documented. Feline calicivirus is a highly contagious and common virus in cat populations worldwide. The virus is able to mutate/change over time (similar to human flu virus) which is why cats that have recovered from calicivirus or are vaccinated may still get mild symptoms if they are re-infected with a new strain. Changes/Problems: The project timeline has been slowed for two reasons. One type is injected; the other is given as drops in the nose. It’s very common in cats and kittens and is usually caused by either the feline herpes virus (FHV) or feline calicivirus (FCV). Cat flu, also known as feline respiratory disease, is a little like a human cold in terms of symptoms. Changes/Problems:The P.I. How have the results been disseminated to communities of interest? Plaque purification, along with generation of additional mutants, will continue following the PI's 2015 sabbatical. Feline calicivirus is resistant to many disinfectants and can survive outside a cat’s body for several days. Dictionary ! MENTAL health symptoms such as depression and anxiety can be triggered in humans who have been in “close contact” with cats, experts have warned. Top. However, Feline calicivirus (FCV) has been accepted as the model for evaluation of disinfectants against Norovirus. What opportunities for training and professional development has the project provided? Nothing Reported A veterinarian will examine t… How have the results been disseminated to communities of interest? Thirteen species are placed in this family, divided among eleven genera. [2] Diseases associated with this family include feline calicivirus (respiratory disease), rabbit hemorrhagic disease virus (often-fatal hemorrhages), and Norwalk group of viruses (gastroenteritis). We investigated eligibility of FCV for anti-viral assay by investigating the stability of infectivity and pH sensitivity in comparison with other viruses. Feline calicivirus (FCV) is a highly contagious virus in cats, and one of the main causes of respiratory infection. How have the results been disseminated to communities of interest? Feline calicivirus (FCV) is a virus that infects domestic cats, causing a range of flu-like symptoms. The Caliciviridae are a family of viruses, members of Class IV of the Baltimore scheme. Replication follows the positive-stranded RNA virus replication model. Sources: Mahy BWJ. The Caliciviridae family comprises positive-sense RNA viruses of medical and veterinary significance. The PI is on sabbatical leave during 2015, but upon his return in January of 2016 will begin analysis of the plaque variants' replication characteristics and gene expression. Feline calicivirus (FCV) is one of the major causes of feline infectious upper respiratory tract disease (cat flu). [2][3] Caliciviruses naturally infect vertebrates, and have been found in a number of organisms such as humans, cattle, pigs, cats, chickens, reptiles, dolphins and amphibians. J Feline Med Surg 2010; 12: 314–321. In addition, large and small plaque variants are being serially passaged through CRFK cells to generate a temporal library of viruses that will be studied for genomic changes over time. In addition, FCV has been passaged in non-feline cell cultures (canine and primate cells) to generate culture-specific strains of virus. Using the feline calicivrus (FCV) as a model system, this research has started looking at mutations/changes n the FCV genome/genetic information, how those mutations might impact the virus's ability to cause disease or the severity of the disease, and possible mechanisms to help explain why some genetic variants cause more severe disease than others. Nothing Reported Changes/Problems:The P.I. The viral proteins expressed were similar in number and size, although the capsid protein of the FCV-Lg variants had a higher molecular weight, which supports previous research reporting a difference in molecular mass of the capsid proteins when comparing large and small plaque variants. Symptoms usually do not last longer than 3 days. To study this, the impact of mutation on FCV replication is being examined through the development of plaque morphology (size) mutants or variants. Translation takes place by leaky scanning, and RNA termination-reinitiation. Nothing Reported The dictionary of virology, 4th edition. They are positive-sense, single-stranded RNA which is not segmented. [1] Thirteen species are placed in this family, divided among eleven genera. Analysis of biological characteristics was conducted, including growth rates, the number of infectious particles, cytopathogenic effects, and proteins expressed. Learning more about this in FCV will help inform studies with the many other important virus pathogens with similar ss(+)RNA genomes causing problems in animals and humans. Pet owners should always bring their cat to see the veterinarian if it shows signs of respiratory disease. Feline calicivirus causes FCV, with the usual symptoms including: Nasal discharge Gingivitis Mouth ulcers The caliciviruses have a simple construction and are not enveloped. Cite This Article. Publications, Progress 10/01/16 to 09/30/17OutputsTarget Audience: Caliciviruses naturally infect vertebrates, and have be… FCV-genomic and mRNA samples were collected for sequence analysis. This research is aimed at understanding some of the dynamics of virus adaptation associated with increasing or decreasing virulence. Feline calicivirus. Humans and dogs are not at risk for catching feline herpes, and cats cannot catch the strains of herpes that humans carry. The capsid appears hexagonal/spherical and has icosahedral symmetry (T=1 or T=3[3]) with a diameter of 35–39 nm. In order to study the effects of mutation on replication, and possibly virulence, of FCV, new sets of plaque variants need to be generated. And it is the same coronavirus that infects people. Nothing Reported The caliciviruses, family Caliciviridae, include important pathogens of humans and animals. How have the results been disseminated to communities of interest? Feline calicivirus (FCV) is frequently used as a surrogate of human norovirus. Cheetahs are the other species of the family Felidae known to become infected naturally. Feline calicivirus (FCV) is an agent that causes upper respiratory disease in cats. There is no evidence that other cat coronaviruses such as the Feline coronavirus UU21, or Feline infectious peritonitis virus, can infect humans or cause any cross-protection against SARS-CoV-2. What opportunities for training and professional development has the project provided? Calicivirus infections commonly cause acute gastroenteritis, which is the inflammation of the stomach and intestines (e.g. Norovirus, except its natural hosts humans and experimental host chimpanzees, neither of which is available for disinfectant efficacy testing on ethical grounds10. How have the results been disseminated to communities of interest? Nothing Reported The human caliciviruses, like other members of the family Caliciviridae, are small (approximately 27 nm), nonenveloped RNA viruses with a single major capsid protein. Nothing Reported Most calicivirus infections do not call for medical attention, but those who are immunocompromised may need to be hospitalized for rehydration therapy. The source of caliciviruses causing gastroenteritis in humans is frequently shellfish, which do not always come from beds contaminated with human waste ( 3 , 4 ). The principal diseases, feline viral rhinotracheitis (FVR; feline herpesvirus type 1), feline calicivirus (FCV), Chlamydia felis, Mycoplasma felis, or combinations of these infections, affect exotic as well as domestic species. Consistently, the FCV-Lg variants replicated faster and to higher titers. Feline calicivirus is a virus that is an important cause of upper respiratory infections and oral disease in cats. Samples of viral mRNA during growth studies are being collected and analysis of those will be undertaken in the next reporting period. Based on plaque morphology - these initial efforts are focused on selecting plaque size mutants (large plaques of greater than 5mm diameter vs. small plaques of less than 1 mm diameter) - at least 3 separate samples of each, large and small, were selected for further development. doi: 10.1371/journal.pone.0059817, International Committee on Taxonomy of Viruses, Virus Pathogen Database and Analysis Resource (ViPR): Caliciviridae, 3D macromolecular structures of Caliciviridae from the EM Data Bank(EMDB), https://en.wikipedia.org/w/index.php?title=Caliciviridae&oldid=1003406902, Creative Commons Attribution-ShareAlike License, This page was last edited on 28 January 2021, at 21:00. Nothing Reported These issues haven't resulted in a change in approach, but a change timeline only. Feline calicivirus (the only member of the group with a seemingly ubiquitous and continuous terrestrial presence) also appears to have ocean reservoirs . It is one of the two important viral causes of respiratory infection in cats, the other being Felid alphaherpesvirus 1. Sapovirus, Norovirus, and Vesivirus have been detected in pigs, making this animal species of particular interest in the study of calicivirus pathogenesis and host range. Progress 11/20/13 to 09/30/18OutputsTarget Audience: Feline Calicivirus Disease Overview Calicivirus is a common virus in cats that causes upper respiratory infection. Feline pneumonitis (Chlamydia psittaci) and mycoplasmal Second, the PI is on sabbatical all of 2015. Diseases associated with this family include feline calicivirus (respiratory disease), rabbit hemorrhagic disease virus (often-fatal hemorrhages), and Norwalk group of viruses (gastroenteritis). Nothing Reported The first mouse norovirus, murine norovirus 1 (MNV-1), was discovered in 2003. Publications, Progress 10/01/14 to 09/30/15OutputsTarget Audience: Virus growth studies in CRFK cells have been performed, initial studies looked at plaque-variant growth rates, identification of FCV-specific RNA in cells, and temporal expression of FCV-specific proteins in CRFK cells. Feline calicivirus, a member of the genus Vesivirus, causes respiratory disease in cats. Cats that have received the nasal vaccine may sneeze frequently for a few days after vaccination; ask your veterinarian if you should expect this or any other side effect from the vaccines. However, the recent application of modern genomic technologies has led to an increased understanding of the virus family. 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